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If you notice that early dosing, which was previously well-tolerated, starts producing nausea after significant weight loss, the changing pharmacokinetics of your lighter body may be the explanation

Biomed Pharmacother 2018;108:952-62.ArticlePubMed 24

It binds to and activates the GLP-1 receptor (GLP-1R) belonging to class B family of G-protein-coupled receptors (GPCRs) in order to exert its regulatory functions

It works by mimicking a natural hormone in the body to regulate blood sugar, reduce appetite, and slow digestion

When calories drop sharply, protein tends to drop with them, and protein is what your muscles need to stay intact