when were glp 1 drugs approved History of GLP-1 Medications The GLP-1 revolution: What UAB

GLP-1 receptors have been identified in various tissues beyond those directly involved in glucose metabolism, raising questions about broader physiological effects

Methods We searched the PUBMED, Embase and Cochrane databases for relevant studies published up until 10 December 2021

Blood pressure improvements were equally striking, with 41% of participants on 8mg doses discontinuing at least one antihypertensive medication by study completion

Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication

doi: 10.1056/NEJMoa1812389 10 NealBPerkovicVMahaffeyKWde ZeeuwDFulcherGEronduNet al

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