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In contrast, metabolic disorders and disorders related to dysfunctions in reward processing (i.e., major depressive disorder and substance use disorders) have received less attention to date

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If tirzepatide can reduce intracranial pressure enough to resolve headaches in IIH, it is plausible that it can reduce pressure enough to lower the migraine threshold in people without a formal IIH diagnosis

Diarrhea: Intestinal transit can become irregular or accelerated in some patients, leading to diarrhea that is typically mild to moderate and temporary

AD: Alzheimers disease