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EMA, FDA and Japan Pharmaceuticals and Medical Devices Agency (PMDA) guidance propose using both AUC (the area under the concentrationtime curve) and C max (the maximum plasma concentration or peak exposure)

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Visual inspection Because internal hemorrhoids are often too soft to be felt during a rectal exam, your doctor might examine the lower portion of your colon and rectum with an anoscope, proctoscope or sigmoidoscope