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For example, oral semaglutide is co-formulated with SNAC, an absorption enhancer that locally increases gastric pH to protect the peptide from pepsin and acid, thereby promoting monomer formation

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The source data of this paper are collected in the following database record: biostudies:S-SCDT-10_1038-S44318-024-00185-3

(Basel) 11, 324

doi: 10.1126/scitranslmed.abl8503 224 MtysCNmethBTOlhATrkMRuppertMKellermayerDet al

12 The substitution of GLP-1 Thr 13 or GIP Ile 7 with Ala obviously decreased their receptor-activating activities 25,26 and the substitution of GIP Ile 7 with Thr decreased its cAMP activity (pEC 50 : 9.769.58;Emax: 9.918.90)
