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Description
Tirzepatide achieved superior reductions in HbA1c and body weight compared with once-weekly semaglutide in head-to-head testing. (Del Prato, The Lancet )

Like other gut side effects, it tends to be mild to moderate

It is released in the gut after eating

In oral semaglutide studies, acid reflux / gastro-oesophageal reflux disease was reported in around 2% of patients

McPherson S, Hardy T, Dufour JF, et al

Meal planning: Pre-planning meals to include specific protein targets simplifies daily monitoring and reduces decision-making when appetite is reduced
