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It does not mean that combining these agents is safe rather, it means that no rigorous scientific evaluation of this combination has been conducted

Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Torne CW, Ryan DH

Rojas Lopez et al

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If left untreated, it may become life-threatening

"Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial." Published in Nature Medicine, Accessed on November 13, 2023 at National Center for Biotechnology Information (NCBI)