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Regulatory authorities continue to review emerging safety data as longer-term studies become available, ensuring that prescribing guidance reflects the most current evidence base

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The pathogenesis of cerebral circulation disorders caused by chronic hyperglycemia is complex and includes mitochondrial dysfunction, neuroinflammation, impaired neurotransmitter systems, and vascular pathologies that lead to cognitive impairment, neurodegeneration, loss of synaptic plasticity, brain aging, and dementia [27]