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Unlike GIP, the fully processed GLP-1 is produced by the neurons within the nucleus of the solitary tract (NST) in the brainstem of rats ( Brain GLP-1Rs, rather than peripheral GLP-1Rs, appear crucial for the weight-reducing effects of GLP-1RAs

While they can help quiet the constant thoughts about food, they don't typically cause a general loss of pleasure or motivation

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They may quiet "food noise." By influencing brain pathways tied to hunger, satiety and reward, GLP-1 drugs may reduce the intrusive, persistent thoughts about food that many people describe as "food noise." Researchers say some patients only realize how constant that mental chatter was once it noticeably quiets on the medication

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Persistent lumps or thickened areas (lipohypertrophy) indicate tissue changes from repeated injections in the same spot