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As a synthetic analog of its endogenous exendin-4, compared with exendin-4, LIXI deleted one proline and added six lysine residues, which increased its binding affinity with the GLP-1R by four times and increased its circulating half-life ( A prospective clinical study from Spain found that besides controlling blood glucose (fasting blood glucose and glycosylated hemoglobin), LIXI can also improve blood lipids, especially total cholesterol and triglyceride ( In clinical studies, LIXI has shown the benefits of weight loss, which is well tolerated by patients and can meet the needs of overweight patients for weight control

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2 Weight loss represents the top 25th percentile of self-reported data from 1,185 Noom Med users prescribed compounded GLP-1s

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Efficacy and safety of liraglutide and semaglutide on weight loss in people with obesity or overweight: A systematic review