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[3] For weight management: If discontinuing tirzepatide prescribed for obesity, consider: Establishing a structured nutrition and exercise program before stopping Transitioning to alternative weight management medications if appropriate Setting realistic expectations about weight regain Implementing behavioral strategies and support systems Regular weight monitoring and early intervention if significant regain occurs Practical discontinuation steps: If cost or access issues are driving discontinuation, discuss these openly with your healthcare team, as patient assistance programs, alternative formulations, or therapeutic substitutes may be available

There is also increasing evidence that these two macrophage populations produce cytokines and chemokines that can create a feed-forward cycle to accelerate intrarenal inflammation in various kidney diseases, including in diabetes (65)

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GLP-1 receptor agonists are recognized for their weight-loss promoting effects through appetite suppression, delayed gastric emptying, and enhanced satiety

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