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The extended-release formulations offered more stable glucose regulation throughout the day and exhibited enhanced glycaemic control relative to their first-generation equivalents in direct comparison analyses (Nauck and Meier 2019)

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Corrected for circulating drug levels, there is little difference in a broad range of pharmacodynamic outcomes when semaglutide is delivered by the oral versus the injectable route. pubmed.ncbi.nlm.nih.gov/34622228/ Does oral semaglutide or injectable semaglutide provide more weight loss