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The Rise of GLP-1 Therapies for Obesity and Type 2 Diabetes GLP-1 RAs: A Paradigm Shift GLP-1 RAs have revolutionized the treatment of both T2DM and obesity

The Deets In November 2024, the Biden administration proposed a major shift: allowing CMS to cover GLP-1s like Wegovy and Zepbound for obesity treatment

rxlist.com (Byetta ) rxlist.com (Byduron ) extended release formulation Keywords Liraglutide Trade Names: Victoza & generic Pharmacology: GLP-1 analog mechanism of action is the same as exenatide Indications: an adjunct to diet and exercise to improve glycemic control in type 2 diabetes mellitus to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes mellitus and established cardiovascular disease Pharmacokinetics: once-daily injection Side Effects: Most common : nausea, diarrhea, vomiting (similar to exenatide) Black Box Warning: RISK OF THYROID C-CELL TUMORS References: Masharani U, Kroon L (2024): Pancreatic Hormones & Antidiabetic Drugs (Chapter 41)

This is essentially a glass cartridge filled with the drug solution, tucked inside a sleek, reusable plastic device roughly the size of a TV remote

Oral Administration of Cinchonine Ameliorated Hepatic Steatosis and Hepatic Fibrosis in Ob/Ob-GAN NASH Mice To further assess the effect of cinchonine on hepatic steatosis, Oil Red O staining was performed

Rapid weight loss using full meal replacement in combination with medical supervision is safe and healthy