semaglutide injections reddit My first injection (almost one year ago) -vs- this morning. SW 250, CW 170. I've been off for a few months. As I've stopped the meds, I've increased my protein intake My decision to stop sema

8 Mitchell et al

No evidence exists of permanent damage from MOTS-c use at typical research doses

ATTAIN-1 (NCT05869903) The key trial for the obesity indication, ATTAIN-1 randomized 3,127 adults with obesity or overweight (without diabetes) to orforglipron 6 mg, 12 mg, or 36 mg versus placebo for 72 weeks

You may also want to discuss fertility, contraception, missed periods, heavy bleeding, and whether any additional testing is recommended

Large-scale clinical trials, including the SELECT cardiovascular outcome trial with over 17,000 participants, have not demonstrated increased overall cancer incidence with these medications compared to placebo groups

However, weight loss achieved with Semaglutide can lead to reductions in stress levels and cortisol production, indirectly benefiting those struggling with stress-related weight gain