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Out-of-Pocket Costs Drive Abandonment Especially in Obesity While payer restrictions and coverage gaps contribute to GLP-1 therapy abandonment, out-of-pocket (OOP) costs remain the most consistent and powerful predictor of non-adherence

Berberine is an isoquinoline alkaloid found in the roots and rhizomes of various medicinal plants, with an extensive history for managing type 2 diabetes [5]

Orlistat (Alli), Sibutramine (Meridia), and Rimonabant (Acomplia) emerged, but some were banned due to cardiovascular and mental health risks

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