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10.1124/pr.108.000604 [DOI] [PMC free article] [PubMed] [Google Scholar] 4.Lee S, Lee DY Glucagon-like peptide-1 and glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes
Cell Proliferat 51 (4), e12443
Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes
Contrave contains naltrexone (an opioid antagonist) and bupropion (an antidepressant)
Furthermore, through the extracellular-signal-regulated kinase 5 (ERK5) pathway, GLP-1 RAs have been shown to increase Krppel-like factor 2 (KLF2) levels and prevent inhibition of mitogen-activated protein kinase (MAPK), which causes downstream anti-inflammatory effects, including decreased leukocyte adhesion [132]
Less commonly prescribed for weight management compared to semaglutide and tirzepatide
