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Nat Commun 9 , 113 (2018)

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Debjani further says that while the individual ingredients in Lemme GLP-1 Daily seem safe and are naturally derived, there are no studies on the specific combination of all three ingredients. She mentions that it can cause some adverse effects including gastrointestinal distress like diarrhoea, gas and bloating

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Effects of LX4211, a dual sodium-dependent glucose cotransporters 1 and 2 inhibitor, on postprandial glucose, insulin, glucagon-like peptide 1, and peptide tyrosine tyrosine in a dose-timing study in healthy subjects