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Comparing Amylin Meds and GLP-1s Because amylin-based therapies may be better tolerated than GLP-1s, some pharmaceutical companies believe these drugs will provide an attractive alternative for patients with obesity, diabetes, or both conditions

10.1038/s12276-018-0183-1 96 ZhouR.LinC.ChengY.ZhuoX.LiQ.XuW.et al (2020)
And that journey doesnt include, Ozempic, she tells Rolling Stone

8.1 Challenges in the optimization of multi-receptor agonists Although multi-receptor agonists such as tirzepatide exhibit enhanced effectiveness, their development poses distinct obstacles that need careful attention
Bushi G, Khatib MN, Rohilla S, et al

To elucidate the protective effect of sitagliptin (i.e., the specificity of DDP4 inhibitor) on N2a cells, the experimental study was categorized into four groups: Na2 cell only (i.e., control group) (group I), N2a cell treated by H 2 O 2 (group II), N2a cell treated by H 2 O 2 and sitagliptin (group III), N2a cell + H 2 O 2 + sitagliptin + LY-294002 (i.e., a specific PI3K inhibitor) (group IV)