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The available evidence does not support a causal association between the Glucagon-Like Peptide-1 receptor agonists (GLP-1) dulaglutide, exenatide, liraglutide, lixisenatide and semaglutide and suicidal and self-injurious thoughts and actions, the Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) has concluded.The review was started in July 2023 following case reports of suicidal thoughts and thoughts of self-injury from people using liraglutide and sem

Persistent blocking of NMDAR and burst-type firing by lateral habenula (LHb) neurons may offer a basis for the long-lasting antidepressant effects of ketamine.

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