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GLP-1 interacts with L 142 , L 145 , and Y 152 , whereas, SR18 interacts with L 141 , L 142 , L 145 , and I 146 of GLP-1R

Ghusn, Wissam, Alan De la Rosa, Daniel Sacoto, Lizeth Cifuentes, Alejandro Campos, Fauzi Feris, Maria Daniela Hurtado, and Andres Acosta

Bariatric surgery + GLP-1 If youve had a malabsorptive bariatric surgery (like a Roux-en-Y gastric bypass or biliopancreatic diversion), birth control pill absorption is already reduced by the surgery

The key protease responsible for the processing of the proglucagon peptide into GLP-1 is Psck1/3, which has shown to be upregulated in -cells during hyperglycaemic, hyperlipidemic, or inflammatory conditions to promote glucose-induced glucagon suppression, a compensatory response to a metabolic insult as in type 2 diabetes (205)

While GLP-1R-decorated nanocarriers can effectively bind and internalize into target cells, quantitative imaging studies indicate that less than 2% of the internalized nucleic acid payload escapes from endosomal compartments into the cytosol

CMAJ Canadian Med Assoc J 172(9):11991209
