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NVO posts elite margins (gross margin near 81%, operating margin around 41%) and remains one of only two players with a commercial oral GLP-1 already on the market

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However, dihydroferulic acid, a microbial metabolite of ferulic acid, markedly stimulated GLP-1 production in L-cells, highlighting a role of gut-mediated metabolism in YMs incretin effects

Barkley lost nearly 50 pounds when he initially started on a GLP-1 medication, but like many Americans, struggled to stay on treatment due to ongoing supply and access issues

GLP-1 receptor agonists caused thyroid C-cell tumors, including medullary thyroid carcinoma, in rodent studies

Liver enzymes (ALT/AST) when dose increases happened