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placebo INDIANAPOLIS, May 21, 2026 /PRNewswire/ -- Eli Lilly and Company (NYSE: LLY), the maker of Zepbound (tirzepatide) and Foundayo (orforglipron), today announced positive topline results from TRIUMPH-1, a Phase 3 clinical trial evaluating the efficacy and safety of retatrutide, an investigational, first-in-class GIP, GLP-1, and glucagon triple hormone receptor agonist, in adults with obesity or overweight and at least one weight-related comorbidity and without diabetes

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Question 4: Do you want a genetic baseline informing your dose before week one

References and Search Strategy Evidence for this article was sourced on 25 February 2026 using PubMed, Google Scholar and Australian government and guideline sites

Im going to walk you through the mechanistic differences, clinical evidence, metabolic outcomes, and practical considerations that actually matter in the Retatrutide vs Cagrilintide debate