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Cost and limited insurance coverage are top barriers to access GLP-1 medications for obesity

Diabetic Ketoacidosis and Ketosis: In individuals with T1DM, GLP-1 RAs were associated with an increased risk of ketosis, including diabetic ketoacidosis (DKA) (Class IV

2024 Dec;20(12):8661-8672

Cold intolerance has emerged as a reported side effect in patients taking tirzepatide, the active ingredient in Mounjaro and other GLP-1 receptor agonist therapies
The firms own SOP states that OOS results must be immediately reported to Quality and the pharmacist-in-charge, and that investigation, root cause analysis, recall, and customer notification procedures shall be followed when applicable. The FDA pointedly notes that the when applicable language effectively makes investigation and notification optional rather than mandatory

Eur J Clin Invest (2003) 33(5):397401.10.1046/j.1365-2362.2003.01161.x 146 HortonFWrightJSmithLHintonPJRobertsonMD
