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doi: 10.2967/jnumed.111.091165

A study on the role of GLP-1RAs in OVX-induced osteoporosis in rats showed that treatment with exendin-4 for 8 weeks improved the trabecular volume, thickness, and number of lumbar vertebrae and femurs

Patients should use them only with medical guidance and regular follow-up

Mounjaro also promotes a second gut hormone known as glucose-dependent insulinotropic polypeptide, or GIP, which is believed to enhance these effects to treat diabetes and obesity

In a subgroup analysis of 140 subjects who underwent dual-energy x-ray absorptiometry (DEXA) scans, those receiving semaglutide lost 6.92 kg of lean mass compared with 1.48 kg in the placebo arm, representing an ~13% reduction in lean mass relative to baseline measures in the total semaglutide population

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