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Randomization across the dose levels were 1:1:1 for PIONEER 1, 3, 8, and 9, whereas PIONEER 2 and 5 included only the 14 mg dose

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DM is responsible for approximately 6.7 million fatalities each year and is associated with various multi-organ complications, including retinopathy, nephropathy, neuropathy, cardiomyopathy, and infertility [80]

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