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Description
Ghrelin Ghrelin is an orexigenic hormone secreted by X/A cells present in the mucosa throughout the length of the GI tract, with the highest abundance in the gastric fundus
The New England Journal of Medicine, 375 (19), 18341844
If you are losing weight and tolerating the medication well at 1 mg, there is no clinical reason to increase further
It usually improves within one to two weeks
The nuance matters because blanket avoidance based on misunderstanding the boxed warning means missing out on a medication that could significantly benefit metabolic health
Finally, amino acid oxidation, particularly of branched-chain amino acids (BCAAs), is a minor source of ATP, contributing less than 2% (34, 48, 49)
