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Upon binding to GLP-1, GLP-1R initiates a cascade of events, starting from activation of adenyl cyclase and cyclic adenosine monophosphate (cAMP) production, which rapidly potentiates glucose-dependent insulin release

We identified P5 in a high-throughput autocrine-based screening of large combinatorial peptide libraries, and show that P5 promotes G-protein signalling comparable to GLP-1 and Exendin-4, but exhibited a significantly reduced -arrestin response

GLP-1 agonists are licensed only for type 2 diabetes and obesity, not rheumatoid arthritis or other autoimmune conditions

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Some users report different side effect profiles when switching between these medications

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