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Increase the dose gradually as prescribed, eat smaller meals, avoid greasy foods, eat slowly and stay well hydrated
It should be noted that physiologic GLP-1R agonism in the periphery mediates food intake reduction via vagal afferent signaling as rats with a surgical subdiaphragmatic vagal deafferentation (SDA) exhibit a more mild food intake suppression in response to acute administration of GLP-1 analogues than sham operated animals (80, 81)
Due to the similar molecular mechanism between T2DM and AD, several drugs for the treatment of T2DM are increasingly being proposed for the treatment of AD (15, 82)
The study established the ~6-day half-life and confirmed once-weekly dosing feasibility
However, among patients with T2DM, there was no association between GLP-1 RAs and new-onset cancers, such as pancreatic cancer, thyroid cancer, and MTC
The findings consistently indicated an association between the GLP-1 RAs use and a lower risk of mortality
