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doi: 10.1210/jc.2008-2808 57 NyuntOCotterillAMArchboldSMWuJYLeongGMVergeCFet al

Thus, combining GIPR and GLP-1R agonism may enhance insulin secretion in patients with T2D by first rescuing dysfunctional beta-cells with GLP-1R agonism followed by additive effects on insulin secretion provided by both receptors

Studies have found that people with overweight or obesity may have a reduction in incretin effects, particularly if they have had frequent weight fluctuations due to yo-yo dieting

Semaglutide's once-weekly dosing schedule offers flexibility, as the injection day can be changed as long as at least 48 hours have elapsed since the last dose

Benzyl alcohol is the most common preservative in multi-dose compounded preparations