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The combination therapy of GLP-1 receptor agonists and metformin demonstrates superior safety over monotherapy, while revealing novel adverse events and demographic-specific risk patterns, thereby offering reliable evidence to inform clinical practice.

Aims/hypothesis Insulin is the primary treatment for type 1 diabetes

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GLP-1 receptor agonists carry specific long-term risks including increased gastrointestinal adverse events (particularly cholelithiasis and GERD), potential ...

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