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The activation of the cGAS-STING pathway has been confirmed to mediate the progression of synovitis and joint destruction by promoting the migration and invasion of fibroblast-like synoviocytes (FLS) and the production of inflammatory factors [22, 46]
Osteoarthritis Cartilage 22(3):363388
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The combination of tirzepatide and metformin is most appropriate for specific patient populations where both medications' complementary mechanisms address clinical needs
Urban residents face amplified exposure to sedentary jobs and processed food intake, further raising risk
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