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Additional evidence comes from a randomized controlled trial by Naing et al., which tested a structured insulin tapering protocol in patients with poorly controlled T2DM on multiple daily insulin injections

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The goal is to build eating habits that are sustainable over the long term

28 , 29 Subgroup analyses from various cardiovascular outcomes trials have also shown that GLP-1 RAs may benefit kidney-related outcomes, including reductions in albuminuria, slower declines in estimated glomerular filtration rate, and a decreased risk of end-stage kidney disease in patients with and without diabetes

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Semaglutide was associated with reduced alcohol consumption and blood alcohol levels during the laboratory drinking task Participants receiving semaglutide drank less (bar graph below) and achieved lower blood alcohol levels during the end of treatment alcohol self-administration paradigm