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Additionally, the effects of GLP-1RAs on long-term cardiovascular outcomes in PCOS remain an important area for future research

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Importantly, sensitivity analyses confirmed the robustness of the effects of weight and BMI, even after excluding lower-quality studies, whereas the effects of waist circumference did not remain significant in these analyses

Rybelsus (semaglutide) is a GLP-1 receptor agonist licensed for type 2 diabetes management, whilst phenterminea sympathomimetic appetite suppressantdoes not hold MHRA marketing authorisation in the UK

These mechanisms operate on different neuroendocrine axes

Various analytical approaches will then be required to address specific business questions - including longitudinal analyses of GLP-1 patients vs