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The main differences are cost, prescription pathway, and no branded marketing

The stability and potency of acylated GLP-1 RAs depends on the site of acylation, the bulkiness and length of the fatty acid chains, and the spacer used between the peptide and fatty acid [62-64], Because the N-terminus is key for receptor binding and activation, acylation in the N-terminal region leads to serious loss of potency

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Looking from 2023 to 2024, the latest year of data available, prescriptions and gross spending for Wegovy (first approved for obesity in 2021, approved for cardiovascular disease in 2024) and Mounjaro (approved for type 2 diabetes in 2022) more than doubled, and prescriptions and gross spending for Zepbound (first approved for obesity in 2023, approved for sleep apnea in 2024) increased more than fivefold