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Liraglutide treatment also increased endothelial nitric oxide synthase (eNOS) and reduced intercellular adhesion molecule-1 (ICAM-1) expression in the aortic endothelium of atherogenic mice models ApoE / mice model [60]

Type 2 diabetes management : FDA-approved doses are calibrated for glycemic control

Although uncontrolled hypothyroidism is associated with increased stroke risk via mechanisms, such as increased vascular resistance, endothelial dysfunction, dyslipidemia, and a pro-thrombotic state [68], the increased stroke risk may be attenuated by the potential cerebrovascular protective effects of GLP-1RA [69]

However, real-world adherence to these medications beyond the short term remains a concern, with previous studies indicating adherence rates between 20% and 50% after 12 months 1-4

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In addition to greater weight loss, participants who took either dose of orforglipron recorded lower average blood sugar levels at the end of the trial than either dose of semaglutide