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b , Mouse brain images showing heatmap of averaged changes in cFOS expression in response to treatments relative to vehicle

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Collectively, these mechanisms encompassing PI3K/Akt activation, modulation of Sirt1-Foxo1, reduction of oxidative stress, inhibition of apoptosis, and cholinergic receptor-mediated anti-inflammatory effects, provide a robust biological basis for curcumins neuroprotective and cytoprotective effects in PD (Nebrisi, 2021)

Nutrients 17 (13), 2229

Then a Danish team tried to synthesise the hormone GLP-1 and inject it into the isolated pancreas of living pigs to test its effects