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A new randomized clinical trial just published inJAMA Psychiatrytested semaglutide (a GLP-1 agonist) in people with schizophrenia, prediabetes, and obesity who were taking antipsychotics

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Lipid Profile Improvements Treatment with retatrutide resulted in favorable changes to lipid profiles: Reduced triglycerides, with bias toward reduction in short-chain and saturated species Decreased LDL and VLDL cholesterol Improved markers associated with enhanced insulin sensitivity and reduced systemic inflammation[3] These changes in lipid metabolism may contribute to retatrutide's cardiometabolic benefits and warrant further investigation for potential cardiovascular outcome benefits
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