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The dose matters

Furthermore, this effect involves hypothalamic AMPK inhibition as pharmacological and genetic activation of AMPK ablates the effect of liraglutide on BAT thermogenesis

Therefore, almost all scientific guidelines now recommend specific treatments for patients with type 2 diabetes based on CVOTs data, namely adding to metformin a SGLT-2 inhibitor or a GLP-1RA with proven CV disease benefit in patients with type 2 diabetes and CV disease, established kidney disease, or HF [7,8,9,10]

We think about metabolic consequences when choosing medications

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Like other GLP-1 medications, it works best when paired with lasting lifestyle changes such as healthy eating, regular activity, and long-term habit support