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Overall, the addition of L-81 to Liposyn did not reduce the cumulative GLP-1 output to the same levels as saline controls, whereas GIP secretion was abolished (Lu et al., 2012)

The oral version, Rybelsus, needs to be taken on an empty stomach

J Clin Gastroenterol 46(4):272284 Raptis DD, Mantzoros CS, Polyzos SA (2023) Fibroblast growth factor-21 as a potential therapeutic target of nonalcoholic fatty liver disease

Tirzepatide is a dual agonist that targets glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)