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Nonetheless, serious adverse events were not significantly different from placebo, suggesting that tirzepatide remains a well-tolerated therapy overall

In these models, this was not the case

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Creatine increases intracellular water demands while tirzepatide can cause dehydration through gastrointestinal side effects

In these trials, MOUNJARO (5 mg, 10 mg, and 15 mg given subcutaneously once weekly) was compared with placebo, semaglutide 1 mg, insulin degludec, and/or insulin glargine [see Clinical Studies (14.2, 14.3, 14.4)]