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Compared to the previous method, this strategy requires fewer protecting groups

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Importantly, these effects on free running were observed in both lean and obese mice and persisted under conditions where food intake was controlled (i.e., pair feeding), pointing to direct effects on motivational processes, rather than reductions that are secondary to hypophagia or weight loss

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Early real-world evidence studies have already begun to confirm a consistent reduction of HHF with SGLT2 inhibitors, and ongoing studies are set to provide more comprehensive insights [73]

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