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thyroid hormone has a long half-life, and its easy to take too much

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In LEAD-2 and LEAD-5, investigators reported that SBP reductions occurred prior to substantial weight loss and may not have been fully explained by changes in body weight

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In another phase 3 analysis, retatrutide at the highest dose reached up to 28.7% weight loss, making it the most potent weight loss medication ever tested in large-scale clinical trials

Targeting GLP-1R expressed on microglia by NLY01 selectively inhibits microglial activation and induction of the reactive astrocyte inducers TNF-, C1q, and IL-1, thus protecting both mouse (5xFAD and 3xTg-AD mice) and human neurons in vitro (human embryonic stem cell (hESC)-derived human cortical neurons) [159]
