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GLP-1 receptor agonists, including liraglutide and semaglutide, demonstrate neuroprotective effects by modulating neuroinflammation and pathways related to neuronal survival [14]

While injectable medications such as Ozempic, Wegovy, Mounjaro, and Zepbound remain widely used, several oral GLP-1 medications are now available

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MOTS-c is a mitochondrial-derived peptide that regulates metabolic homeostasis, while 5-amino-1mq inhibits NNMT to improve cellular energy metabolism

Future Cardiol

Reflection paper on regulatory requirements for the development of medicinal products for chronic non-infectious liver diseases (PBC, PSC, NASH) (EMA, 2018)