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Furthermore, as your body begins to burn through stored glycogen (the way your body stores carbohydrates), it releases a significant amount of water

American Society of Anesthesiologists

Human studies examining circulating METRNL levels have produced heterogeneous results, reflecting differences in metabolic state, physical activity, and assay methodology

If fatigue is problematic, discussing a slower titration schedule with your prescriber may allow better tolerance whilst the body adjusts

[DOI] [PubMed] [Google Scholar] 62.Li DQ, Jing X, Salehi A, et al

Effect of linagliptin on glucose metabolism and pancreatic beta cell function in patients with persistent prediabetes after metformin and lifestyle
