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For both academic and clinical cardiology, this is a call to rethink prevention: integrating metabolism, obesity, and cardiovascular risk into a single, more effective approach

Therefore, enhancing bioavailability and stability will be key in the future, although breakthroughs in once-weekly oral GLP-1 drugs are still awaited

Shyangdan DS, Royle P, Clar C, Sharma P, Waugh N, Snaith A

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In previous studies, orforglipron reduced body weight by 12.4% and improved cardiometabolic risk factors after 72 weeks in adults with obesity without diabetes

It is a dual GIP and GLP-1 receptor agonist, meaning it activates two incretin pathways simultaneously