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Additionally, gastrointestinal side effects, such as nausea, vomiting, and diarrhea, are commonly associated with GLP-1 receptor agonists, especially during the initial phase of treatment

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Over time, escalation in dose, frequency, or polysubstance combinations may follow

Chaperoning G protein-coupled receptors: from cell biology to therapeutics

It is a sign that the peptide is active and the body is adjusting
