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Additionally, semaglutide slows gastric emptying, meaning food remains in the stomach for longer, which contributes to prolonged satiety

Despite these lifestyle changes and the use of metformin, GA is unable to achieve significant weight loss, and her HbA1C only drops to 8%

These formulations became more accessible during the 2022-2024 FDA-declared shortages of brand-name products, when compounding played a larger role in meeting demand

Yaribeygi et al., 2019

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Some patients are able to sustain weight loss by making the healthy behaviors learned during treatment a permanent part of their lifestyle, while others may regain weight if they fail to adopt lasting changes