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3 Pharmacotherapeutic potential of GIP and GLP-1 3.1 Therapeutic potential in T2DM Despite being the first identified incretin, GIP was initially disregarded as a viable therapeutic approach for T2DM

Back Zander, M, Madsbad, S, Madsen, JL, Holst, JJ (9 March 2002) 'Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study', The Lancet , 359/9309, 824-30

Well, our liver loves to create some glucose when it senses glucagon

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LY3298176, a novel long-acting GIP/GLP-1 coagonist, shows enhanced activity on weight loss and energy utilization whilst maintaining its efficacy for glycaemic control
