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Diabetic cardiomyopathy increases mortality in diabetic patients by causing heart failure and is characterized by a multitude of interrelated systems that are influenced, including calcium homeostasis, renin-angiotensin system, protein kinase C signaling pathway, metabolism, mitochondria, fibrosis, and oxidative stress [89]

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Endothelial cells (ECs) covering the inner surface of the vascular wall can generate, activate, and release various vasoactive substances and regulate cardiovascular function, including nitric oxide (NO), prostacyclin (PGI2), endothelin-1 (ET-1), and endothelium-derived contracting factors (EDCF)

GLP-1 is secreted by the small intestine in response to nutrient ingestion

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