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CLINICAL TRIAL EVIDENCE FOR DUAL GLP-1/GLUCAGON RAs AND TRIPLE AGONISTS IN MASH Survodutide Survodutide, a weekly dual GLP-1/GCG agonist, was assessed in a phase 2 dose-finding trial (NCT04771273) including 293 individuals with histologically confirmed MASH and fibrosis stages F1-F3 [46]

That trial (announced in 2023) is the first to prove that treating obesity pharmacologically can prevent cardiovascular events , a groundbreaking concept

VillageMDs Scaleback : After a long period of clinic expansion including an $8.9B purchase of Summit Health, VillageMD is exiting certain markets including Indiana as part of its announced cost cutting plan from October

Under the MFN framework, Medicare and Medicaid programs are expected to access select GLP-1s at approximately $245 per month, though coverage for weight-loss-only use remains limited or excluded in many states

The numbers of patients in each subgroup are reported

Trial reports also describe adverse events and discontinuation rates within controlled protocols